It has to be "The Blues Brothers"(Universal Pictures).
"There are 106 miles to Chicago, we have a full tank of gas, half a pack of cigarettes, it's dark and we're wearing sunglasses" - Elwood Blues.
"Hit it!" - Joliet Jake.
With those lines, one of the most epic movie car chases begins as the Blues Brothers (Dan Aykroyd and John Belushi) try to make it to Daley Plaza in Chicago to save the orphanage they were raised in. Half the fun is watching so many cars chase through the streets of Chicago.
The Blues Brothers drive the Bluesmobile: a former police 1974 Dodge Monaco -- "It's got a cop motor, a 440 cubic inch plant, it's got cop tires, cop suspensions, cop shocks." They are pursued by literally dozens of police cars and an RV. At the time of its release, "The Blues Brothers" held the record for the most cars destroyed in a film -- 103 -- until the sequel came out and destroyed 104. Watch it!