The Blazers were playing their fourth game in seven days on the second night of a back-to-back yet they never gave their fresher opponents a chance.

Simmons was aggressive, going to the rim when needed with seven out of 12 from the field.

His fellow Australian Jonah Bolden was given extended time on court in Embiid's absence.

Bolden played a season-high 26 minutes for eight points and eight rebounds.

The 76ers are back in action on Wednesday (AEDT) as they continue their five-game road trip against the Los Angeles Clippers.

In other games, the Los Angeles Lakers won for the first time in three games without an injured LeBron James, beating the Sacramento Kings 121-114.

Kawhi Leonard scored 27 points and grabbed nine rebounds as the Toronto Raptors defeated the visiting Chicago Bulls 95-89.

Evan Fournier scored 13 points and made his second game-winning shot of the season to lift Orlando over visiting Detroit, 109-107.

Harrison Barnes turned a last-minute steal into a pair of free throws and Dennis Smith jnr hit a go-ahead shot with 24.8 seconds remaining to rally hosts Dallas over Oklahoma City 105-103.

The Minnesota Timberwolves defeated the Miami Heat 113-104.