"Commissioner Hayne has called out the clear need for change," he said, adding the process had been a valuable one.
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"We note that the commissioner has concluded that a number of matters regarding the group’s conduct, including in relation to superannuation, warrant further investigation by relevant regulators and we will cooperate fully with these investigations."
Mr Comyn is likely to face a grilling when the CBA releases its financial results for the first half of the financial year on Wednesday.
The bank is expected to notch up a $4.9 billion profit this week, despite the bank's bottom line bearing the scars of high compliance and compensation costs from the scandals sweeping the sector.
"[The commission] has highlighted failings both in our business and across the wider financial services industry," he said.
"As challenging as the royal commission process has been, CBA will be a better bank as a result."
The report was released on the same day that the corporate regulator lost patience with CBA's progress on setting right failures that saw it charge customers fees without delivering any service.
"There is still much work ahead to earn back trust, but we are determined to restore broad respect and support for the important role that a major financial institution like CBA has to play in our economy and community," he said.
ANZ chief executive Shayne Elliott, who spent some of Monday morning selling The Big Issue outside the bank's headquarters, said the inquiry would change the industry for the better.
“This is a defining moment for both our company and industry," he said.
"It has been a humbling experience for me, our leaders and all our people - we have learnt from this and accepted responsibility for our failings.
Mr Elliott said the bank needed to ensure the failures detailed in the inquiry were not repeated.
“I recognise the size and nature of our compliance and culture challenge. And I am determined we deal with it."
Westpac chief executive Brian Hartzer said the inquiry could be a "turning point" for the industry.
Our focus remains on learning from the mistakes of the past and preventing them from happening again.
Westpac CEO Brian Hartzer
“The royal commission has been a confronting, thorough and important process," he said.
"Our focus remains on learning from the mistakes of the past and preventing them from happening again."
National Australia Bank chairman Ken Henry and chief executive Andrew Thorburn came in for some particularly stinging criticism from Commissioner Hayne in his report.
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“Having heard from both the CEO, Mr Thorburn, and the chair, Dr Henry, I am not as confident as I would wish to be that the lessons of the past have been learned,” Commissioner Hayne said.
"Overall, my fear – that there may be a wide gap between the public face NAB seeks to show and what it does in practice – remains."
National Australia Bank released a statement saying it would review the report as well as the government's response and "provide further updates as appropriate".
Mathew Dunckley is business editor for The Sydney Morning Herald and The Age. Based in our Melbourne newsroom, Mathew has almost 20 years experience as a journalist and editor.