A manhunt is under way for a gunman after a doctor was shot dead at his Brisbane home.

The 56-year-old general practitioner was packing his car in the garage of his MacGregor home with the door open when a man pulled up in a light-coloured sedan or hatchback and shot him in the chest about 11.40pm on Monday.

“The man’s family was home at the time, his wife and two adult children,” Detective Acting Inspector Steven McCartney said.

The man was taken to Princess Alexandra hospital in a critical condition and died there.

The shooter remains at large and it is believed the pair did not know each other.

Police suspect only one person was involved but say it could be more. They are unable to say what type of gun was used or at what range the shooter fired from.

The victim worked as a doctor in Brisbane’s Chinese community on the city’s south side.

His wife is an overseas-trained doctor, and their two adult children are also studying to become doctors.

Police have asked for anyone in the MacGregor area, particularly on Delfin Street bounded by Mains Road and Granadilla Street, to come forward with any CCTV or dashcam footage.