Three men have been charged after police seized $1.6 million worth of cocaine from a home in Adelaide's western suburbs. 

Australian Border Force officers and detectives from the Serious and Organised Crime Branch (SOCB) searched a house at Fulham Gardens yesterday. 

SA Police said officers found 3.87 kilograms of cocaine inside, which has a street value of about $1.6 million. 

As a result of the initial search, police attended a number of other premises throughout the western and north-eastern suburbs which resulted in the seizure of $504,000 cash. 

Police said four vehicles and two motorcycles were also seized, which they allege were used in the connection to trafficking illicit drugs. 

A 37-year-old Findon man, a 28-year-old Seaton man and a 24-year-old man from Broadview have been charged with attempting to traffic in a large commercial quantity of controlled drugs. 

They have been refused bail and are expected to appear in the Adelaide Magistrates Court today. 

"These arrests and seizures are another example of SAPOL working together with Australian Border Force, Department of Home Affairs and the Australian Federal Police to apprehend people who attempt to import large amounts of illicit substances into South Australia that cause great community harm," Detective Acting Superintendent Denise Gray from SOCB said. 

"It is an example of the determination of the SAPOL Serious and Organised Crime Branch to bring these offenders to justice and confiscate their assets."

Police have asked for anyone with information which may assist the ongoing investigation to contact Crime Stoppers.