"No one and no country should impose its will on others, or bully others under the guise of multilateralism," Wei said.

"We notice Secretary Austin's remarks on the US Indo-Pacific strategy. To us, the strategy is an attempt to build an exclusive, small group in the name of a free and open Indo-Pacific, to hijack countries in our region and target one specific country. It is a strategy to create conflict," Wei said.

"Fight to the very end"

But Wei -- who met Austin in a bilateral meeting on Friday afternoon -- reserved some of his harshest criticisms for Washington's stance on Taiwan, the democratically governed island that Beijing considers its territory despite never having ruled it.

Austin had on Friday said the US would continue to support Taiwan with the means to defend itself, including arms sales which China sees as a violation of its sovereignty.

"China will definitely realize its reunification. ... It is a historical trend that no one, no force can stop," Wei said.

And the People's Liberation Army was prepared to spill blood to enforce that if necessary, he said.

"Let me make this clear," Wei said. "If anyone dares to secede Taiwan from China, we will not hesitate to fight. We will fight at all costs. And we will fight to the very end."

The Chinese defense minister said the road the US is taking in the region is one his country would never go down.

"The order of human civilization must be based on the rule of law. Otherwise, the law of the jungle will prevail," Wei said.

"China will never seek hegemony or engage in military expansion or an arms race. We do not bully others, but we will not allow others to bully us," he said.

Wei leads China's Ministry of National Defense, but is not the top military official in the Chinese Communist Party's Central Military Commission, which controls China's armed forces under Chinese leader Xi Jinping.

Regional tensions

China has faced a barrage of criticism during the Shangri-La conference.

Without mentioning China by name, Japanese Prime Minister Fumio Kishida said Friday that the Asian security situation is prompting Tokyo to substantially increase its defense budget and consider acquiring "counterstrike weapons," of the type not now in its arsenal.

Japanese forces and Australian forces, among other US allies and partners, have been operating in the South China Sea, almost all of which China claims as its sovereign territory.

China has militarized various man-made islands in the 1.3 million square mile waterway.

But Wei inferred that it was the US that was muscling in by sending naval ships into the waterway.

"Some big power has long practiced navigation hegemony on the pretext of freedom of navigation," Wei said.

He said the US and China are at a critical juncture in their relationship, but contended the ball is in Washington's court when it comes to diffusing tensions.

Washington must stop "smearing" Beijing and "interfering in China's internal affairs" for relations to improve, Wei said.

"It will be a historic and strategic mistake to insist on taking China as a threat and of an adversary or even an enemy," he said.

If Washington can treat Beijing with "mutual respect," there is room for both nations to prosper, Wei contended.

But he had a stern warning if the United States chose otherwise.

"If you want to cooperate, we should promote mutual benefits and win-win results. However, if you want confrontation, we will fight to the end."