Novak Djokovic has destroyed Australia's Alex De Minaur in straight sets to keep his quest for a 10th Australian Open title alive.

The Serbian star was at his brilliant best for the full three sets as he gave the Australian no chance in a 6-2, 6-1, 6-2 drubbing on Rod Laver Arena.

The match took just two hours as Djokovic dominated the Australian, who simply could not match the Serb's power or skill.

It was total dominance from Djokovic, who didn't even face a break point throughout the match.

The nine-times champion was unapologetic about the thrashing he had just dished out.

"I cannot say I am sorry that you didn't see a longer match," Djokovic said.

"I thought the first four or five games were quite close.

"One break of serve and I started to feel more loose and free and I felt he was more nervous.

"I kept my focus all the way through and played the best match of this year so far."

Things started out well enough for De Minaur, who held his first service game to love.

It was as good as things would get.

Djokovic made inroads on the next De Minaur service game and, after that, broke him at will.

In fact, he broke him in six of the next nine service games.

Some had thought this match might test the heavily-strapped hamstring of Djokovic, such is De Minaur's ability to make his opponent hit plenty of shots, but that was not the case here.

Djokovic moved well and bullied De Minaur throughout the match as he racked up nearly triple the winners of the hometown favourite, and even shut out the Australian crowd.

They were silenced by the Serbian's brilliance, in fact the chants of "Nole, Nole Nole" were sometimes notable.

Djokovic said the hamstring — which he injured in Adelaide against Daniil Medvedev — felt fine on Monday night.

"Tonight it wasn't obvious I was dealing with an injury," Djokovic said.

"I didn't feel anything.

"I thank my medical team and my phsyio, anybody that really helped me."

Djokovic will now play fifth-seeded Russian Andrey Rublev in the quarterfinals.