Injury and a rampant Karen Khachanov have killed off Sebastian Korda's dream of emulating his dad and winning the Australian Open.

Korda's father Petr won the title 25 years ago but Sebastian's run came to an end in shattering circumstances against Khachanov.

Korda suffered a wrist injury during the second set against and only won won a single game after receiving treatment, retiring at 7-6 (7/5), 6-3, 3-0.

Korda called for the trainer at 2-3 down in the second set and had his right wrist assessed then strapped but it did little to ease the pain.

That pain was etched on his face every time he was forced to hit multiple forehands in a rally, as he winced and shook his head, all the while looking at his girlfriend and coach Radek Stepanek.

After dropping the second set Korda went for a bathroom break but the writing was on the wall.

Khachanov, who had been impressive early on and had controlled the bulk of the match pre-injury advancing to his first Australian Open semifinal.

"It's not the way you want to win," Khachanov said before paying tribute to Korda.

"Sebastian beat one of my friends in Daniil [Medvedev] and Hurkacz in five — so big applause to him."

For Khachanov it's his second straight semifinal in a slam after making the final four at the US Open, before losing to Casper Ruud.

He said that experience has given him a newfound confidence that he can be a contender at the majors.

"I kind of re-invented myself," he said.

"I would say I always believe in myself but there are always ups and downs and sometimes when you have this great result it just shows you what you're capable of and then you start to believe more and more.

"So this belief and self-confidence I think appear much stronger after the US Open.

"I just hope to continue that way, and to grow as a person and as a sportsman."

Khachanov will play either Stefanos Tsitsipas or Jiri Lehecka in the semis.