One of inner Sydney's largest weekend markets will close at the end of this month.

The Glebe Markets website announced the closure, with February 25 to be the last day of trading.

Stallholders said they felt blindsided when they were informed by an email from the markets' management which cited personal reasons for the closure.

"It's put myself and a lot of people into a bit of a panic," long-time stallholder Joseph Stellino told ABC Radio Sydney.

Mr Stellino says the markets bring at least 10,000 people to the area on the Saturday and that the closure will also impact neighbouring businesses.

"A lot of the businesses will be severely affected due to the influx of people that come into the area on that particular day," he said.

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Fellow stallholder Jacky Pateman said she was disappointed as she felt the markets were booming.

"I think at the moment, it is the most vibrant and energetic it's ever been," Ms Pateman said.

ABC Radio Sydney has contacted Glebe Markets operator David McCumstie for comment.

The markets, which are held on the grounds of Glebe Public School, were started in 1992.

A Department of Education spokesperson said the contract to operate the markets was due to expire in March and the department had no plans to close the markets.

"The markets have been a mainstay at Glebe Public School for more than 30 years and play an important role in bringing the school and wider Glebe community together," the spokesperson said.

Mr Stellino said he hoped a new operator would take on the tender and retain the creative spirit of the markets.