Sam Kerr has nicked the advantage in her duel with Australia teammate Ellie Carpenter as Chelsea prevailed 1-0 against holders Lyon in the first leg of their Champions League quarterfinal clash.

The two Matildas, so influential for their club sides, were both at the heart of the action in the Parc Olympique Lyonnais as the closely contested tie was decided by Guro Reiten's fine 28th-minute winner.

Kerr, feeding largely off scraps from Chelsea's counterattacks, still proved hard to handle for the home defence and came close to scoring on several occasions.

Carpenter, getting back to her best after her recovery from the ACL injury suffered in last year's Champions League final that kept her sidelined for nine months, grew increasingly influential after the break, marauding forward from fullback.

Even though Lyon, who have won the European crown in six of the past seven seasons, hit the woodwork in the second half, it will be Chelsea carrying the crucial advantage into next week's return leg at Stamford Bridge.

On course to take a fourth successive Women's Super League title in England after a fine campaign, the Blues are desperately seeking the one major trophy to so far elude them during Kerr's dazzling spell at the club.

They could have enjoyed an even more substantial advantage.

After Reiten's curled shot whipped past Lyon goalkeeper Christiane Endler, Chelsea almost doubled their lead when Lauren James's effort bounced off the post.

Eight-time winners Lyon dominated much of the second period, and came close to an equaliser when Delphine Cascarino's shot struck the woodwork after Chelsea failed to clear their lines.

Chelsea had several chances to put the game, and possibly the tie, to bed but they failed to land a decisive second, with Kerr blasting over with a left-footed drive only for the offside flag to be belatedly and incorrectly raised.

AAP