St Kilda are paying a fearful price for their upset AFL win over Collingwood, with Mason Wood and Liam Henry sidelined and star forward Max King facing suspension.

Wood has paid a high price for his courage and will undergo surgery over the next day for the broken collarbone he suffered in the first quarter of Thursday night's MCG clash.

He was also concussed in the nasty collision with teammate Zaine Cordy as they went for a mark.

Wood will be out of action for six weeks.

Not long after the Saints confirmed Wood's prognosis on Friday afternoon, the AFL announced King had been offered a one-game ban for rough conduct against the Magpies' Finlay Macrae.

Unless the Saints successfully take the case to the tribunal, King will miss next week's game against Essendon.

Then came more bad news, with St Kilda releasing a second statement to confirm Henry has a high-grade left hamstring strain that will sideline him for six to eight weeks.

Henry was one of the Saints' best players until he went off in the last term.

The Saints had been hopeful it was only bad cramp.

"This is obviously a terrible blow for Liam, who has impressed in his first two games at the club," Saints football boss David Misson said.

"Liam's setback is far greater than we initially thought, especially given he has never had an injury of this type before."

The game on Friday night was stopped for several minutes as medical teams came onto the MCG to attend to the 30-year-old Wood.

He was taken off the ground on a stretcher, before going to hospital for scans.

His team went on to beat defending premiers Collingwood by 15 points for St Kilda's first win of the season.

The club confirmed on Friday that Wood had been concussed, and would now undergo surgery within 24 hours on his injured collarbone.

"Obviously you'd prefer your players not get injured at all, but considering the angle and way Mason landed, we could've been dealing with something far more serious," Misson said.

"Mason's set for surgery in the next few hours, which is a great start. He'll now get his rehab started pretty much straight away.

"If we know anything about Mase it's that he's extremely diligent and professional in how he looks after his body, so we know he'll be doing everything he can to get right and be back on the field as soon as possible."

ABC/AAP