Gold Coast captain Tino Fa'asuamaleaui will miss the rest of the NRL season after scans confirmed he ruptured his anterior cruciate ligament (ACL) against Canterbury on Saturday.

Fa'asuamaleaui had scans in Sydney on Saturday night after the Titans' 32-0 loss and a further analysis by a club doctor on Sunday morning revealed the worst possible news.

The injury is also a dagger in the heart of Queensland ahead of this year's State of Origin series, as the 24-year-old was set to feature for the Maroons.

The representative prop was assisted from the field in the 66th minute at Belmore on Saturday after his right knee twisted in a tackle when he was carrying the football.

The injury has left the Titans in a dire situation after their winless start to the season.

They recorded a 28-4 loss to St George Illawarra in round one, when Fa'asuamaleaui ran for 182 metres and made 28 tackles in a stand-out display in a badly beaten team.

The loss of Fa'asuamaleaui is a devastating blow to the Titans' finals hopes and leaves coach Des Hasler with a massive void in what has already been an underwhelming start to the season.

The Titans started their campaign with injury concerns, with fullback Jayden Campbell (patella) and second-rower David Fifita (torn pectoral) yet to play in the NRL.

Campbell returned to action on Saturday in the Queensland Cup with Tweed Heads and could be available for the round four NRL clash with the Dolphins on Saturday at Robina.

For the Maroons, Fa'asuamaleaui's setback comes on the back of also losing Dolphins forward Tom Gilbert to a season-ending ACL injury.

AAP