The Brisbane Lions and GWS Giants meet at the Gabba in a clash that has massive finals implications, as the Kangaroos and Eagles face off in a match that will determine the top of the draft order later this year.
Later, Fremantle and Geelong will do battle at Perth Stadium as both teams aim to solidify their finals spots, with that clash set for 4.35pm.
That match will be followed by a double-header as Essendon hosts the Gold Coast Suns at Docklands Stadium, while Melbourne hosts Port Adelaide at the MCG, with both matches commencing at 7.30pm.
Follow the live blog below, keep up to date with all the latest stats in our ScoreCentre, and tune in to our live radio coverage.
All times are AEST.
BL v GWS: The Big O strikes as Lions dominance continues
It's two goals in a minute for the Lions!
Following the centre bounce, Oscar McInerney ghosts into the forward line and takes a mark that's virtually uncontested 35m out directly in front.
McInerney drills the set shot and it's a great start now this for the Lions.
BL v GWS: Daniher gets out the back for Lions' opener
We've got out first goal of the afternoon and it's come at the nine-minute mark of the first term.
The ball is sent inside 50 and Joe Daniher is one out with Sam Taylor and the ball gets out the back.
Daniher wins the footrace and soccers it through.
The Lions having plenty of the footy early, they've got 35 disposals to 24 and have five inside 50s to one.
BL vs GWS: Review denies Cadman after crafty finish
Aaron Cadman thinks he's kicked one of the goals of the season, but the ARC rules that the ball has juuust clipped the inside of the right goalpost.
We're still waiting for the first goal of the afternoon. Brisbane will feel like they should have kicked it, but Joe Daniher missed an easy set shot from 30m out directly in front.
Dayne Zorko already up to four touches for Brisbane.
BL vs GWS: Key match-ups to start first quarter
GWS has wasted no time by sending their tagger Toby Bedford straight to Lachie Neale.
In the Lions' defence, Harris Andrews is trying to mark Coleman Medal leader Jesse Hogan.
What a match-up that one will be!
Brandon Starcevich is shadowing Giants skipper Toby Greene.
Stars everywhere out there.
Play underway in Brisbane and Tasmania!
We're off and running in the first two of five matches on Saturday's AFL slate.
Stay tuned as we bring you all the big updates!
How we're going to cover things during the first double-header
So as you're well aware, there's two matches running concurrently this afternoon.
As the Brisbane-GWS clash is the one with finals implications, we'll bring you more regular updates from that one.
However, there will still be constant updates from North-West Coast as well, so do not fear if you're a fan of those teams, you will not get ignored!
Kangaroos vs Eagles team news - Retiring Gaff the sub
Both North Melbourne and West Coast have no late changes for this afternoon's clash.
Andrew Gaff, who announced his retirement earlier in the week, will start as West Coast's sub.
Lions vs Giants team news - No late changes
Both Brisbane and GWS are lining up as originally selected at the Gabba this afternoon.
Here are your subs for that match.
Welcome!
Good afternoon footy fans and welcome to ABC Sport's live coverage of today's AFL slate.
It's a jam packed slate of five matches today so strap yourselves in.
Here's the full fixture so you know exactly what time everyone is playing, all times are AEST.
- 1.45pm: Brisbane Lions vs GWS Giants @ Gabba
- 1.45pm: North Melbourne vs West Coast @ Bellerive Oval
- 4.35pm: Fremantle vs Geelong @ Perth Stadium
- 7.30pm: Essendon vs Gold Coast @ Docklands Stadium
- 7.30pm: Melbourne vs Port Adelaide @ MCG
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