"They [shots] just went down tonight," Leonard said, after he matched his career-best scoring effort in the NBA.

Power forward Pascal Siakam, with 29 points and seven rebounds, was the only other Raptors player to score in double figures.

Melbourne-born Simmons ended the game with 14 points, nine rebounds, three assists and just two turnovers.

Simmons sank seven of his eight field goals but the 76ers - who shot at less than 40 per cent from the field - were no match for the potent Raptors.

The 76ers' other Australian, Jonah Bolden, had three points in 13 minutes off the bench while All-Star centre Joel Embiid, still carrying a knee injury, had a sub-par 16 points and eight rebounds.

Game two of the best-of-seven series is in Toronto on Monday.

Patty Mills' San Antonio Spurs play a decisive first-round game seven at the Denver Nuggets in the late game.

The winners play the Portland Trail Blazers in the western conference semi- finals.

AAP