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"We haven't named the XI yet but I'd say those two will be 12th and 13th man," Langer told reporters of Bancroft and Neser.
Bancroft's omission confirms Joe Burns will resume his Test career at the top of the order alongside David Warner, with Travis Head to slot in at five or six in a middle order featuring Marnus Labuschagne, Steve Smith and Matthew Wade.
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Left out of the XI in four of the five Ashes Tests, Mitchell Starc will be a part of a three-man pace attack with Pat Cummins and Josh Hazlewood.
Probable XI: David Warner, Joe Burns, Marnus Labuschagne, Steve Smith, Travis Head, Matthew Wade, Tim Paine (c, wk), Pat Cummins, Mitchell Starc, Nathan Lyon, Josh Hazlewood
Unlucky to be left out of Australia’s Ashes squad, Burns’ combination with Warner and Australia’s desire to start the match on the right foot bolstered his case for a recall.
“He’s got a very good first innings record,” Langer said of Burns, who averaged 47.25 in the first innings.
“I know Davey likes batting with him.
“I obviously have some understanding in how important it is for the openers to get along really well, and work really well with each other and understand each other."
Langer is hopeful the duo can end Australia's trouble at the top of the order, which has lacked stability since the retirement of Chris Rogers after the Ashes.
“What we need to do is to get our top 3 cemented and get that as strong as possible. It’s a pivotal part of winning games of cricket.
“I’m confident that the odd couple will get out there and like we’ve seen in the past will form a really good partnership.”
The first Test between Australia and Pakistan begins on Thursday at the Gabba.