A police spokeswoman said the man was shot between about 7.30pm and 7.45pm on Monday after raising his weapon at police. She could not say how many shots police fired.

Just before midnight (1am Tuesday AEDT), police confirmed the 48-year-old Woodridge man had died.

The spokeswoman said there was nothing to indicate the incident, at a business centre on Compton Road, Stretton, was ideologically motivated.

The 48-year-old first entered the precinct about 1.20pm, when police were advised of a disturbance.

But it wasn't until about 3pm police say he brandished a firearm, prompting specialist officers to rush to the scene.

The police spokeswoman said there were members of the public locked in the business centre throughout, but they were separated from the alleged gunman and not threatened or injured.

"Five members of the public remained locked inside the premises in a separate room to the man," police later said, in a statement.

The 48-year-old was fighting for life at the Princess Alexandra Hospital on Monday night.

Police remained on the scene while the ethical standards command investigated the incident, as part of standard procedure in any police shooting.

Police had earlier shut down traffic on Compton Road in both directions and evacuated several businesses

Detours were in place to Condamine and Gowan Roads, causing significant delays.

Compton Road reopened westbound about 8.30pm.

It's believed the man entered the Compton Road business in Stretton, armed with a firearm, this afternoon.

Police have shut down traffic on Compton Road in both directions and it's understood several highly trained specialist police officers are on the scene.

Detours are in place to Condamine and Gowan Roads, with significant delays expected for some time.