WHO Coronavirus (COVID-19) Dashboard, https://covid19.who.int/

de Wit, E. et al. SARS and MERS: Recent insights into emerging coronaviruses. Nat Rev Microbiol. 14, 523–534 (2016).

Article  Google Scholar 

Song, Z. et al. From SARS to MERS, thrusting coronaviruses into the spotlight. Viruses 11, 59 (2019).

Article  CAS  Google Scholar 

Johns Hopkins Unuversity. Coronavirus Resource Center. Mortality analyses. https://coronavirus.jhu.edu/data/mortality Accessed July 214, 2022.

Grasselli, G. et al. Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy region. Italy. JAMA. 323, 1574–1581 (2020).

Article  CAS  Google Scholar 

Guan, W. J. et al. Clinical characteristics of coronavirus disease 2019 in China. N. Engl. J. Med. 382, 1708–1720 (2020).

Article  CAS  Google Scholar 

Xu, X. W. et al. Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series. BMJ 368, m606 (2020).

Article  Google Scholar 

Wu, Z. & McGoogan, J. M. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: Summary of a report of 72314 cases from the Chinese center for disease control and prevention. JAMA 323, 1239–1242 (2020).

Article  CAS  Google Scholar 

Huang, C. et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan China. Lancet 395, 497–506 (2020).

Article  CAS  Google Scholar 

Richardson, S. et al. Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York city area. JAMA 323, 2052–2059 (2020).

Article  CAS  Google Scholar 

Zheng, J. SARS-CoV-2: An emerging coronavirus that causes a global threat. Int. J. Biol. Sci. 16, 1678–1685 (2020).

Article  CAS  Google Scholar 

Gold, J. A. W. et al. Characteristics and clinical outcomes of adult patients hospitalized with COVID-19—Georgia, March 2020. MMWR Morb. Mortal. Wkly. Rep. 69(18), 545–550 (2020).

Article  CAS  Google Scholar 

Maggi, E., Canonica, G. W. & Moretta, L. COVID-19: Unanswered questions on immune response and pathogenesis. J. Allergy Clin. Immunol. 146(1), 18–22 (2020).

Article  CAS  Google Scholar 

Pandey, K. et al. Animal models for SARS-CoV-2 research: A comprehensive literature review. Transbound. Emerg. Dis. 68(4), 1868–1885 (2021).

Article  CAS  Google Scholar 

Shou, S. et al. Animal Models for COVID-19: Hamsters, mouse, ferret, mink, tree shrew, and non-human primates. Front. Microbiol. 12, 626553 (2021).

Article  Google Scholar 

Boukhvalova, M. S., Prince, G. A. & Blanco, J. C. G. The cotton rat model of respiratory viral infections. Biologicals 37(3), 152–159 (2009).

Article  CAS  Google Scholar 

Ottolini, M. G. et al. A cotton rat model of human parainfluenza 3 laryngotracheitis: Virus growth, pathology, and therapy. J. Infect. Dis. 186, 1713–1717 (2002).

Article  Google Scholar 

Patel, M. C. et al. Enterovirus D-68 infection, prophylaxis, and vaccination in a novel permissive animal model, the cotton rat (Sigmodon hispidus). PLoS ONE 11, e0166336 (2016).

Article  Google Scholar 

Blanco, J. C. et al. Prophylactic antibody treatment and intramuscular immunization reduce infectious human Rhinovirus 16 load in the lower respiratory tract of challenged cotton rats. Trials Vaccinol. 3, 52–60 (2014).

Article  Google Scholar 

Rodriguez, W. J. et al. Respiratory syncytial virus (RSV) immune globulin intravenous therapy for RSV lower respiratory tract infection in infants and young children at high risk for severe RSV infections: Respiratory syncytial virus immune globulin study group. Pediatrics 99, 454–461 (1997).

Article  CAS  Google Scholar 

Porter, D. D. et al. Pathogenesis of human parainfluenza virus 3 infection in two species of cotton rats: Sigmodon hispidus develops bronchiolitis, while Sigmodon fulviventer develops interstitial pneumonia. J. Virol. 65, 103–111 (1991).

Article  CAS  Google Scholar 

Strickland, B. A. et al. Microbial community structure and composition is associated with host species and sex in Sigmodon sp. cotton rats. Anim Microbiome 3, 29 (2021).

Article  CAS  Google Scholar 

Strickland, B. A. et al. Species-specific transcriptomic changes upon respiratory syncytial virus infection in cotton rats. Sci. Rep. 12(1), 16579 (2022).

Article  ADS  CAS  Google Scholar 

Wyllie, A. L. Saliva as a gold-standard sample for SARS-CoV-2 detection. Lancet Respir. Med. 9(6), 562–564 (2021).

Article  Google Scholar 

Huang, N. et al. SARS-CoV-2 infection of the oral cavity and saliva. Nat. Med. 27(5), 892–903 (2021).

Article  CAS  Google Scholar 

Muñoz-Fontela, C. et al. Animal models for COVID-19. Nature 586(7830), 509–515 (2020).

Article  ADS  Google Scholar 

Pandey, K. et al. Animal models for SARS-CoV-2 research: A comprehensive literature review. Transbound. Emerg Dis. 68(4), 1868–1885 (2021).

Article  CAS  Google Scholar 

Killingley, B. et al. Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge in young adults. Nat. Med. 28(5), 1031–1041 (2021).

Article  Google Scholar 

Watts, D. M. et al. Evaluation of cotton rats as a model for severe acute respiratory syndrome. Vector Borne Zoonotic Dis. 8(3), 339–344 (2008).

Article  CAS  Google Scholar 

van Doremalen, N. et al. ChAdOx1 nCoV-19 vaccine prevents SARS-CoV-2 pneumonia in rhesus macaques. Nature 586(7830), 578–582 (2020).

Article  ADS  Google Scholar 

Vogel, A. B. et al. BNT162b vaccines protect rhesus macaques from SARS-CoV-2. Nature 592(7853), 283–289 (2021).

Article  ADS  CAS  Google Scholar 

Bleier, B. S., Ramanathan, M. Jr. & Lane, A. P. COVID-19 vaccines may not prevent nasal SARS-CoV-2 infection and asymptomatic transmission. Otolaryngol. Head Neck Surg. 164(2), 305–307 (2021).

Article  Google Scholar 

López-Pintor, R. M. et al. Xerostomia, hyposalivation, and salivary flow in diabetes patients. J. Diabetes Res. 2016, 4372852 (2016).

Article  Google Scholar 

Singh, D. K. et al. Responses to acute infection with SARS-CoV-2 in the lungs of rhesus macaques, baboons and marmosets. Nat. Microbiol. 6(1), 73–86 (2021).

Article  CAS  Google Scholar 

Dinnon, K. H. 3rd. et al. A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures. Nature 586, 560–566 (2020).

Article  ADS  Google Scholar 

Curtis, S. J. et al. Age-dependent replication of respiratory syncytial virus in the cotton rat. Exp. Biol. Med. (Maywood) 227(9), 799–802 (2002).

Article  CAS  Google Scholar 

Boukhvalova, M. S. et al. Age-related differences in pulmonary cytokine response to respiratory syncytial virus infection: Modulation by anti-inflammatory and antiviral treatment. J. Infect. Dis. 195(4), 511–518 (2007).

Article  CAS  Google Scholar 

Guichelaar, T. et al. Impaired immune response to vaccination against infection with human respiratory syncytial virus at advanced age. J. Virol. 88(17), 9744–9750 (2014).

Article  Google Scholar 

Boukhvalova, M. S. et al. Effect of aging on immunogenicity and efficacy of inactivated influenza vaccines in cotton rats Sigmodon hispidus. Hum. Vaccin Immunother. 17(1), 133–145 (2021).

Article  CAS  Google Scholar 

Al-Samkari, H. et al. COVID-19 and coagulation: Bleeding and thrombotic manifestations of SARS-CoV-2 infection. Blood 136(4), 489–500 (2020).

Article  CAS  Google Scholar 

Borczuk, A. C. et al. COVID-19 pulmonary pathology: A multi-institutional autopsy cohort from Italy and New York city. Mod. Pathol. 33(11), 2156–2168 (2020).

Article  CAS  Google Scholar 

Ottestad, W. & Søvik, S. COVID-19 patients with respiratory failure: What can we learn from aviation medicine?. Br. J. Anaesth. 125(3), e280–e281 (2020).

Article  CAS  Google Scholar 

Tobin, M. J., Laghi, F. & Jubran, A. Why COVID-19 silent hypoxemia is baffling to physicians. Am. J. Respir. Crit. Care Med. 202(3), 356–360 (2020).

Article  CAS  Google Scholar 

Gattinoni, L. et al. COVID-19 Pneumonia: Different respiratory treatments for different phenotypes?. Intensive Care Med. 46(6), 1099–1102 (2020).

Article  CAS  Google Scholar 

Reva, I. et al. Erythrocytes as a target of SARS-CoV-2 in pathogenesis of COVID-19. Arch. Euromedica. 10(3), 5–11 (2020).

Article  Google Scholar 

Malkmohammad, E. M. M. et al. Silent hypoxia: Higher NO in red blood cells of COVID-19 patients. BMC Pulm. Med. 20, 269 (2020).

Article  Google Scholar 

Yáñez, A., Helen, S., Goodridge, H. S., Daniel Gozalbo, D. & Gil, M. L. TLRs control hematopoiesis during infection. Eur. J. Immunol. 43(10), 2526–2533 (2013).

Article  Google Scholar 

Zheng, M. et al. TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines. Nat. Immunol. 22, 829–838 (2021).

Article  CAS  Google Scholar 

Harris, C. K. et a